Screening Biological Drug Product Formulations

All of the data in a fraction of the time with a fraction of the sample 

The new SUPR-CM from Protein Stable is a truly high throughput formulations system which uses 96/384-well microplates throughout the process.  With sensitivity beyond all other microplate readers sample amounts are no longer a barrier to screening large numbers of formulations on multiple samples.  Using microplates throughout the process simplifies sample preparation and removes the need for an additional loading step, minimizing overall costs and eliminating expensive proprietary consumables.  Full spectrum reading of the fluorescence signal combined with powerful analysis software, delivers high quality data and quickly informs decisions about which formulations can be progressed.  A full plate of 384 samples can be read in as little as 2.5 minutes, removing a key bottleneck in the process.

 

When we say user-friendly, we mean it!

Past experience has taught you that user friendly software means it does not have the power to perform well or perhaps that great software may be rather complex and difficult to use.  Now is the time for a new experience.  Flexible, easy to use software which can be set up and running in moments and powerful enough to analyze the most complex data.  

A modular approach

The SUPR-CM is available as a stability screening plate reader only or can also be combined with best-of-the-best liquid handling and lab scale automation to offer the full formulations experience.  By using a modular approach, Protein Stable can offer systems for all space and budget requirements and the chance to upgrade at a later date to gain advances in walk-away time and throughput.    

No compromise Data

Chemical melt methods for Protein Stability analysis offer the highest quality data, not only on melting denaturant concentration (Cm) but also thermodynamic parameters essential for understanding of the folding and unfolding process.   Given the diversity of proteins, there is a large variation in unfolding rates and numbers of transition states, thus requiring a flexible approach to the methodology. The SUPR-CM system allows each module to do its job to the best, meaning that there are no compromises in the process – for example, you will not be restricted to a set incubation period for the chemical melts – select a time that is best for your protein.