Keeping up with Protein Stable
Aggregation is a major challenge in biologics development, and can be assessed using isothermal chemical denaturation.
Forced degradation studies are used routinely within biologic development including accelerated stability studies. They are also useful in understanding the stability of biologic on a more fundamental level.
The stability of a monoclonal antibody is quantified for different buffer solutions including MOPS, TRIS, sodium phosphate and sodium citrate. Read more.